U.S. Patents Awarded to Inventors in Massachusetts (Feb. 9)

(Targeted News Service Via Acquire Media NewsEdge) Targeted News Service Targeted News Service ALEXANDRIA, Va., Feb. 9 -- The following federal patents were awarded to inventors in Massachusetts.

*** Cardiofocus Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Cardiofocus, Norton, Mass., has been assigned a patent (8,366,705) developed by four co-inventors for "coaxial catheter instruments for ablation with radiant energy." The co-inventors are Jeffrey M. Arnold, Wellesley, Mass., Edward L. Sinofsky, Dennis, Mass., Lincoln S. Baxter, Centerville, Mass., and Norman E. Farr, Monument Beach, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A cardiac ablation instrument capable of removing blood from a treatment area is provided. The instrument includes a catheter configured to deliver a distal end thereof to a patient's heart. The instrument can also include an expandable element coupled to the distal end of the catheter wherein the expandable member is configured to be positioned adjacent a target area thereby defining a treatment area between the expandable member and the target area. Further, the instrument can include an irrigation mechanism configured to dispense an irrigation fluid from the catheter thereby displacing blood from the treatment area. Additionally, the instrument includes an energy emitter configured to deliver energy to tissue within the treatment area. The instrument can also include a contact sensor configured to determine the presence of such blood within the treatment area. Methods for ablating tissue are also provided." The patent application was filed on April 16, 2009 (12/424,757). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,705.PN.&OS=PN/83,66,705&RS=PN/83,66,705 Written by Amal Ahmed; edited by Jaya Anand.

*** Massachusetts Institute of Technology Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Massachusetts Institute of Technology, Cambridge, Mass., has been assigned a patent (8,366,627) developed by Faisal Mahmood Kashif, Cambridge, Mass., Thomas Heldt, Cambridge, Mass., and George Cheeran Verghese, Newton, Mass., for "systems, devices and methods for noninvasive or minimally-invasive estimation of intracranial pressure and cerebrovascular autoregulation." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The systems, devices, and methods described herein provide for the estimation and monitoring of cerebrovascular system properties and intracranial pressure (ICP) from one or more measurements or measured signals. These measured signals may include central or peripheral arterial blood pressure (ABP), and cerebral blood flow (CBF) or cerebral blood flow velocity (CBFV). The measured signals may be acquired noninvasively or minimally-invasively. The measured signals may be used to estimate parameters and variables of a computational model that is representative of the physiological relationships among the cerebral flows and pressures. The computational model may include at least one resistive element, at least one compliance element, and a representation of ICP." The patent application was filed on Sept. 8, 2009 (12/555,713). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,627.PN.&OS=PN/83,66,627&RS=PN/83,66,627 Written by Amal Ahmed; edited by Jaya Anand.

*** General Hospital Assigned Patent ALEXANDRIA, Va., Feb. 9 -- The General Hospital, Boston, has been assigned a patent (8,366,704) developed by Charles P. Lin, Arlington, Mass., and Clemens Alt, Watertown, Mass., for "optical devices and methods for selective and conventional photocoagulation of the retinal pigment epithelium." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention provides devices and methods for applying radiation to the retina of a patient. In one embodiment, an apparatus includes a radiation source for generating a radiation beam suitable for absorption by retinal pigment epithelial cells. One or more optical components are included to direct the beam onto the retina. A scanner is optically coupled to the radiation source to control movement of the beam in two dimensions to allow a scan over the retina. A controller applies control signals to the scanner to adjust beam movement to illuminate a plurality of retinal locations in a temporal sequence according to a predefined pattern. The device can be operated in one mode to effect selective targeting of retinal pigment epithelial cells, or in another mode to effect thermal photocoagulation of the retina." The patent application was filed on May 25, 2012 (13/480,955). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,704.PN.&OS=PN/83,66,704&RS=PN/83,66,704 Written by Amal Ahmed; edited by Jaya Anand.

*** Avedro Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Avedro, Waltham, Mass., has been assigned a patent (8,366,689) developed by John Marshall, Farnborough, United Kingdom, Ali Hussein, Waltham, Mass., and David Muller, Boston, for a "method for making structural changes in corneal fibrils." The abstract of the patent published by the U.S. Patent and Trademark Office states: "In a system for stabilizing a pattern of structural changes in corneal fibrils, an eye treatment system causes corneal fibrils of a cornea of an eye to transition from a first structure to a second structure. An application device applies a cross-linking element to the corneal fibrils. An activating device applies an initiating element to the corneal fibrils and activates the cross-linking element. The cross-linking element causes cross-linking in the corneal fibrils to preserve the second structure of the corneal fibrils. Another application device may apply a cross-linking breaker to the corneal fibrils. The cross-linking breaker halts or reverses at least partially the cross-linking in the corneal fibrils. Another activating device applies an initiating element to the corneal fibrils and activates the cross-linking breaker. Advantageously, the cross-linking breaker provides greater control over the amount and progress of cross-linking that occurs in the corneal fibrils." The patent application was filed on Sept. 30, 2009 (12/570,959). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,689.PN.&OS=PN/83,66,689&RS=PN/83,66,689 Written by Amal Ahmed; edited by Jaya Anand.

*** Zimmer Spine Assigned Patent for Apparatus for Connecting a Longitudinal Member to a Bone Portion ALEXANDRIA, Va., Feb. 9 -- Zimmer Spine, Minneapolis, has been assigned a patent (8,366,747) developed by Alan E. Shluzas, West Roxbury, Mass., for an "apparatus for connecting a longitudinal member to a bone portion." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A device for provides access to a surgical location within a patient. The device has an elongate body that has a proximal portion, a distal portion, a first slot segment, and a second slot segment that is angled relative to said first slot segment. The elongate body defines a passage for accessing the surgical location with surgical instruments. The elongate body has a contracted configuration for insertion into the patient and an expanded configuration for providing access to the surgical location. The cross-sectional area of the passage at a first location of the elongate body is greater than the cross-sectional area of said passage at a second location of the elongate body. A movable tab is configured to extend into the second slot segment when the elongate body is in the expanded configuration to retain the elongate body in the expanded configuration." The patent application was filed on Oct. 20, 2004 (10/969,293). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,747.PN.&OS=PN/83,66,747&RS=PN/83,66,747 Written by Amal Ahmed; edited by Jaya Anand.

*** Boston Scientific Scimed Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Boston Scientific Scimed, Maple Grove, Minn., has been assigned a patent (8,366,708) developed by Kimbolt Young, Newtonville, Mass., for "medical needles and electrodes with improved bending stiffness." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A device for penetrating tissue includes an elongated element having a distal end, a proximal end, a body extending between the distal and the proximal ends, and a lumen located within at least a portion of the body, wherein the lumen has a cross-sectional shape that is a polygon. A device for penetrating tissue includes an elongated element having a distal end, a proximal end, and a body extending between the distal and the proximal ends, at least a portion of the body having a cross-sectional profile that is a polygon, wherein the elongated element is a cannula." The patent application was filed on June 29, 2012 (13/539,062). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,708.PN.&OS=PN/83,66,708&RS=PN/83,66,708 Written by Amal Ahmed; edited by Jaya Anand.

*** Juniper Networks Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Juniper Networks, Sunnyvale, Calif., has been assigned a patent (8,369,224) developed by five co-inventors for "combining network endpoint policy results." The co-inventors are Roger Chickering, Granite Bay, Calif., Stephen R. Hanna, Bedford, Mass., Paul Funk, Cambridge, Mass., Panagiotis Kouriouris, Cupertino, Calif., and Paul James Kirner, Jamaica Plain, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "An endpoint integrity system controls access to resources of a protected network for endpoint devices attempting to access the protected network. The system may include a number of evaluation modules that communicate with an endpoint device. The evaluation modules generate policy results for the endpoint device, in which each of the policy results assume one of three or more states, called a multi-state policy result. The multi-state policy results are combined to produce a combined Boolean policy result." The patent application was filed on Sept. 8, 2006 (11/530,189). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,69,224.PN.&OS=PN/83,69,224&RS=PN/83,69,224 Written by Amal Ahmed; edited by Jaya Anand.

*** Angio Dynamics Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Angio Dynamics, Latham, N.Y., has been assigned a patent (8,366,687) developed by seven co-inventors for an "injection access port with chamfered top hat septum design." The co-inventors are Mark Girard, Waltham, Mass., Todd Beaupre, Reading, Mass., Benjamin Bell, Haverhill, Mass., Mark Wolfson, Wellesley, Mass., Richard Nisil, Blackstone, Mass., Jeffrey J. Crowley, Milford, Mass., and Nathan Murphy, Westborough, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "An access port comprises a housing with a first opening and a self sealing septum sealing the first opening, the septum including an attachment portion for securing the septum to the housing, the attachment portion including a chamfer which, when the septum is mounted within the housing is subject to a force oriented substantially perpendicularly with respect to a plane of the outer surface, the chamfered portion redirecting a portion of the force to compress the outer surface. A septum for an access port comprises an attachment portion for abutting a septum seat of the access port and an operative surface permitting penetration by a needle and resealing itself after removal of the needle in combination with a chamfered portion providing a transition between the attachment portion and the operative surface, the chamfered portion re-directing a component of a force applied to the chamfered portion to compress the operative surface." The patent application was filed on Jan. 6, 2004 (10/752,257). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,687.PN.&OS=PN/83,66,687&RS=PN/83,66,687 Written by Amal Ahmed; edited by Jaya Anand.

*** Avaya Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Avaya, Basking Ridge, N.J., has been assigned a patent (8,369,220) developed by five co-inventors for "routing a flow of elastic traffic." The co-inventors are Bakul Khanna, Lexington, Mass., Jozef Babiarz, Kanata, Canada, Ali Labed, Ottawa, Delfin Montuno, Kanata, Canada, and Hesham El-Bakoury, San Jose, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "To route a flow of elastic traffic, plural candidate paths are identified for the flow of elastic traffic. A particular path from among the plural candidate paths is selected to route the flow of elastic traffic according to criteria including numbers of flows on respective candidate paths and measured performances of the respective candidate paths." The patent application was filed on Dec. 31, 2007 (12/006,128). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,69,220.PN.&OS=PN/83,69,220&RS=PN/83,69,220 Written by Amal Ahmed; edited by Jaya Anand.

*** Boston Scientific Scimed Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Boston Scientific Scimed, Maple Grove, Minn., has been assigned a patent (8,366,725) developed by Michael S. H. Chu, Brookline, Mass., for placing sutures.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A suturing instrument including multiple needle and suture assemblies that are at least partially disposed within the suturing instrument allows a surgeon to place multiple sutures intercorporally without having to remove the instrument from a surgical site and reload the instrument between placing each suture. The suturing instrument includes an elongate body member that includes a distal portion defining an opening. The suturing instrument further includes a first needle disposed within the opening, a second needle disposed within the opening, and a needle deployment mechanism disposed at least partially within the elongate body member and connectable sequentially to the first needle and the second needle." The patent application was filed on Oct. 12, 2010 (12/902,676). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,725.PN.&OS=PN/83,66,725&RS=PN/83,66,725 Written by Amal Ahmed; edited by Jaya Anand.

*** Verizon Services Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Verizon Services, Ashburn, Va., has been assigned a patent (8,369,229) developed by Lawrence W. Jones, Woburn, Mass., for "methods for monitoring delivery performance of a packet flow between reference nodes." The abstract of the patent published by the U.S. Patent and Trademark Office states: "In one of many possible embodiments, a method may comprise using one or more packet delivery monitoring packets to monitor packet delivery between a first reference node and a second reference node communicatively coupled to one another by at least one network path, each of said PDM packets comprising an Internet Control Message Protocol packet modified to include at least one packet delivery monitoring extension." The patent application was filed on Aug. 2, 2006 (11/497,841). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,69,229.PN.&OS=PN/83,69,229&RS=PN/83,69,229 Written by Amal Ahmed; edited by Jaya Anand.

*** Smith & Nephew Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Smith & Nephew, Memphis, Tenn., has been assigned a patent (8,366,744) developed by four co-inventors for an "apparatus for tissue repair." The co-inventors are Raymond A. Bojarski, Attleboro, Mass., George Sikora, Bridgewater, Mass., Paul Alexander Torrie, Marblehead, Mass., and Steven W. Ek, Bolton, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "An apparatus for tissue repair includes first and second fixation members configured to secure tissue together, a flexible coupling member coupling the first and second fixation members, the flexible coupling member having two terminal ends, one of the two terminal ends terminating adjacent one of the first and second fixation members, the flexible coupling member slidably coupled to at least one of the first and second fixation members such that when the other of the two terminal ends of the flexible coupling member is pulled, a length of the flexible coupling member between the first and second fixation members is shortened, and a closed loop of flexible material, the flexible coupling member being slidably received through the closed loop of flexible material." The patent application was filed on Sept. 23, 2011 (13/242,499). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,744.PN.&OS=PN/83,66,744&RS=PN/83,66,744 Written by Amal Ahmed; edited by Jaya Anand.

*** Olympus Endo Technology America Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Olympus Endo Technology America, Southborough, Mass., has been assigned a patent (8,366,674) developed by James J. Frassica, Chelmsford, Mass., and Robert E. Ailinger, Norwood, Mass., for a rotate-to-advance catheterization system.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Apparatus for accessing a bodily passageway, the apparatus comprising: a flexible tube having a distal end and a proximal end, a longitudinal axis extending between the distal end and the proximal end, and a lumen extending from the distal end to the proximal end, the lumen being sized to receive matter to be transported through the bodily passageway; and an external thread disposed over the distal end of the tube, the external thread having a sufficient structural integrity, and a sufficient surface profile, such that when the tube is disposed in a bodily passageway, rotation of the tube about the longitudinal axis will result in longitudinal motion of the tube along said bodily passageway." The patent application was filed on Aug. 24, 2010 (12/806,905). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,66,674.PN.&OS=PN/83,66,674&RS=PN/83,66,674 Written by Amal Ahmed; edited by Jaya Anand.

*** Janssen Biotech Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Janssen Biotech, Horsham, Pa., has been assigned a patent (8,367,656) developed by Matthew Sansone, Lowell, Mass., for "polymorphs of 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]- heptanoic acid S,S dioxide and methods of making and using the same." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Disclosed herein are novel polymorphs of 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]- heptanoic acid S,S-dioxide. Also described herein are novel pharmaceutical compositions comprising one or more 7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]- heptanoic acid S,S-dioxide polymorphs, methods of making, and related methods of treatment." The patent application was filed on March 4, 2008 (12/041,747). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,656&OS=8,367,656&RS=8,367,656 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Curis Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Curis, Lexington, Mass., has been assigned a patent (8,367,663) developed by four co-inventors for "phosphoinositide 3-kinase inhibitors with a zinc binding moiety." The co-inventors are Xiong Cai, Bedford, Mass., Haixiao Zhai, Bedford, Mass., Cheng-Jung Lai, Belmont, Mass., and Changgeng Qian, Wayland, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The instant application relates to deazapurines, thienopyrimidines and furopyrimidines with zinc-binding moiety based derivatives and their use in the treatment of phosphoinositide 3-kinase related diseases and disorders such as cancer. The instant application further relates to the the treatment of histone deacetylase related disorders and diseases related to both histone deacetylase and phosphoinositide 3-kinase." The patent application was filed on Jan. 8, 2010 (12/684,594). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,663&OS=8,367,663&RS=8,367,663 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Tetraphase Pharmaceuticals Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Tetraphase Pharmaceuticals, Watertown, Mass., has been assigned a patent (8,367,654) developed by five co-inventors for 8-AZA tetracycline compounds. The co-inventors are Roger B. Clark, Lexington, Mass., Minsheng He, Watertown, Mass., Louis Plamondon, Belmont, Mass., Xiao-Yi Xiao, San Diego, and Magnus P. Ronn, Melrose, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention is directed to a compound represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof. The variables for Structural Formula I are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula I and its therapeutic use. ##STR00001##." The patent application was filed on May 7, 2010 (13/319,307). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,654&OS=8,367,654&RS=8,367,654 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Galectin Therapeutics Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Galectin Therapeutics, Norcross, Ga., has been assigned a patent (8,367,638) developed by David Platt, Newton, Mass., Eliezer Zomer, Newton, Mass., and Anatole Klyosov, Newton, Mass., for "galactose-pronged polysaccharides in a formulation for antifibrotic therapies." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin; (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) matrix metalloproteinases MMP 2 and MMP9; (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-.beta.1; (xi) endothelin receptor antagonists; and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis." The patent application was filed on Dec. 21, 2011 (13/333,497). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,638&OS=8,367,638&RS=8,367,638 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** ProNAi Therapeutics, Novosom Assigned Patent ALEXANDRIA, Va., Feb. 9 -- ProNAi Therapeutics, Kalamazoo, Mich., and Novosom, Halle, Germany, have been assigned a patent (8,367,628) developed by six co-inventors for an amphoteric liposome formulation. The co-inventors are Neal Clifford Goodwin, Plainwell, Mich., Gerold Endert, Halle, Germany, Natalie Herzog, Cottbus, Germany, Yvonne Kerwitz, Penzberg, Germany, Steffen Panzner, Halle, Germany, and Wendi Rodrigueza, Roslindale, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer." The patent application was filed on May 27, 2005 (12/085,893). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,628&OS=8,367,628&RS=8,367,628 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Vertex Pharmaceuticals Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Vertex Pharmaceuticals, Cambridge, Mass., has been assigned a patent (8,367,660) developed by six co-inventors for "modulators of cystic fibrosis transmembrane conductance regulator." The co-inventors are Hayley Binch, Encinitas, Calif., Dennis Hurley, San Marcos, Calif., Lev T.D. Fanning, San Marcos, Calif., Peter D.J. Grootenhuis, San Diego, Martyn Botfield, Concord, Mass., and Fredrick Van Goor, San Diego.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using such CFTR modulators." The patent application was filed on Dec. 21, 2009 (12/643,188). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,660&OS=8,367,660&RS=8,367,660 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Acceleron Pharma Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Acceleron Pharma, Cambridge, Mass., has been assigned a patent (8,367,611) developed by John Knopf, Carlisle, Mass., Jasbir Seehra, Lexington, Mass., and Matthew L. Sherman, Newton, Mass., for "activin-actriia antagonists for inhibiting germ cell maturation." The abstract of the patent published by the U.S. Patent and Trademark Office states: " In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation. " The patent application was filed on May 19, 2011 (13/111,393). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,611&OS=8,367,611&RS=8,367,611 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Enanta Pharmaceuticals Assigned Patent for Cyclosporin Analogues for Preventing or Treating Hepatitis C Infection ALEXANDRIA, Va., Feb. 9 -- Enanta Pharmaceuticals, Watertown, Mass., has been assigned a patent (8,367,618) developed by four co-inventors for "cyclosporin analogues for preventing or treating hepatitis C infection." The co-inventors are Yat Sun Or, Watertown, Mass, Guoqiang Wang, Belmont, Mass., Jiang Long, Wayland, Mass., and Xuri Gao, Watertown, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to cyclosporin analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporin analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds." The patent application was filed on Jan. 30, 2010 (12/697,215). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,618&OS=8,367,618&RS=8,367,618 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Massachusetts Institute of Technology Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Massachusetts Institute of Technology, Cambridge, Mass., has been assigned a patent (8,367,525) developed by four co-inventors for "rapid patterning of nanostructures." The co-inventors are Joseph M. Jacobson, Newton, Mass., Jae-bum Joo, Cambridge, Mass., Jon Varsanik, Allston, Mass., and Vikrant Agnihotri, Jersey City, N.J.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A process for forming nanostructures comprises generating charged nanoparticles with an electrospray system and introduction of the charged nanoparticles to a substrate, so that the particles adhere to the substrate in order to form the desired structure. The charged nanoparticles may be directed to a target position by at least one deflector in the electrospray apparatus, which may also include a column optic system. The adhered nanoparticles may be sintered to form the structure. The electrospray apparatus may be single source, multi-source injection, or multi-source selection. An array of electrospray apparatuses with deflectors may be used concurrently to form the structure." The patent application was filed on Jan. 23, 2010 (12/692,610). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,525&OS=8,367,525&RS=8,367,525 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Children's Medical Center Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Children's Medical Center, Boston, has been assigned a patent (8,367,352) developed by four co-inventors for a "promoting axon regeneration in the adult CNS through control of protein translation." The co-inventors are Zhigang He, Boston, Kevin Park, Boston, Kai Liu, Boston, and Yang Hu, Boston.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron." The patent application was filed on June 6, 2009 (12/479,805). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,352&OS=8,367,352&RS=8,367,352 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** BioChemics Assigned Patent ALEXANDRIA, Va., Feb. 9 -- BioChemics, Danvers, Mass., has been assigned a patent (8,367,122) developed by five co-inventors for a "control of blood vessel physiology to treat skin disorders." The co-inventors are Laura Stephens, Danvers, Mass., John J. Masiz, Topsfield, Mass., Stephen G. Carter, Andover, Mass., Zhen Zhu, Tewksbury, Mass., and Kanu Patel, Londonderry, N.H.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "In a method for treating an affected skin region of a patient having a skin disorder, a vasodilation composition is applied to an affected skin region of a patient, the affected skin region exhibiting a skin disorder characterized by at least one abnormal blood vessel, and the affected skin region is then treated so as to non-invasively disrupt tissue architecture, e.g., by inducing ischemia, of the at least one abnormal blood vessel. A vasoconstriction composition can then be applied to the skin region to cause vasoconstriction of the at least one blood vessel in order to promote healing." The patent application was filed on June 11, 2009 (12/483,073). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,122.PN.&OS=PN/8,367,122&RS=PN/8,367,122 Written by Kusum Sangma; edited by Anand Kumar.

*** Seacoast Neuroscience Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Seacoast Neuroscience, Amesbury, Mass., has been assigned a patent (8,367,116) developed by Daniel Pratt, Amesbury, Mass., Samuel S. Macausland, Wellesley, Mass., and Keith Baker, Danvers, Mass., for a "buoyant polymer particles for delivery of therapeutic agents to the central nervous system." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention provides compositions and methods for treating a subject who has suffered from a central nervous system disorder. More particularly, the invention provides sustained polymeric drug delivery systems having a polymer particle, a therapeutic agent, and a buoyancy agent for direct delivery of therapeutic agents into the central nervous system." The patent application was filed on March 18, 2011 (13/051,331). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,116.PN.&OS=PN/8,367,116&RS=PN/8,367,116 Written by Kusum Sangma; edited by Anand Kumar.

*** Saint-Gobain Ceramics & Plastics Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Saint-Gobain Ceramics & Plastics, Worcester, Mass., has been assigned a patent (8,367,265) developed by James A. Salvatore, Sutton, Mass., Vignesh Rajamani, Wilmington, Mass., and Abhijit Dutta, Shrewsbury, Mass., for a "uniform gas distribution through channels of SOFC." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A solid oxide fuel cell includes an anode layer, an electrolyte layer over the anode layer, and a cathode layer over the electrolyte layer. At least one of the anode layer and the cathode layer defines a gas manifold. The gas manifold includes a gas inlet, defined by an edge of the anode layer or cathode layer, a gas outlet, defined by the same or a different edge of the anode layer or cathode layer, and a plurality of gas flow channels in fluid communication with the gas inlet and gas outlet. The gas flow channels can have diameters that conduct flow of gas from the gas inlet at substantially equal flow rates among the gas flow channels." The patent application was filed on Dec. 15, 2009 (12/638,781). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,265.PN.&OS=PN/8,367,265&RS=PN/8,367,265 Written by Kusum Sangma; edited by Anand Kumar.

*** Baxter Assigned Patent for Methods of Processing Compositions Containing Microparticles ALEXANDRIA, Va., Feb. 9 -- Baxter International, Deerfield, Ill., and Baxter Healthcare, Glattpark (Opfikon), CH, have been assigned a patent (8,367,427) developed by six co-inventors for "methods of processing compositions containing microparticles." The co-inventors are Ramin Darvari, Lexington, Mass., Adam Lambert, North Canton, Ohio, Julia E. Rashba-Step, Newton, Mass., Mark X. Yang, Newton, Mass., Junhong Zhang, Needham, Mass., and Ed O'Connell, Brighton, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A method for processing multi-phasic dispersions is provided. The method comprises providing a multi-phasic dispersion including dispersed and continuous phases, providing one or more non-solvents comprising an aqueous solution containing at least one multivalent cation, exposing the multi-phasic dispersion to the non-solvent to form a suspension containing one or more liquid phases and the solid microparticles, and removing at least a portion of the resulting one or more liquid phases while retaining at least the microparticles, thereby removing at least a portion of the non-volatile material from the microparticles." The patent application was filed on Aug. 20, 2008 (12/195,092). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,427&OS=8,367,427&RS=8,367,427 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** New England Biolabs Assigned Patent ALEXANDRIA, Va., Feb. 9 -- New England Biolabs, Ipswich, Mass., has been assigned a patent (8,367,331) developed by George R. Feehery, West Newbury, Mass., and Sriharsa Pradhan, Wenham, Mass., for a "method for enriching methylated CpG sequences." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Compositions and methods are provided for facilitating the enrichment of single-stranded DNA containing methylated CpG in a mixture containing methylated and unmethylated DNA. The compositions relate to methylation-binding protein domains that selectively bind to methylated single strand DNA. In embodiments of the invention, the methylated DNA is eluted in 0.4M-0.6M NaCl while the unmethylated single strand DNA is eluted in less than 0.4M salt. The ability to readily enrich for methylated DNA permits high throughput sequencing of the methylated DNA and identification of abnormal methylation patterns associated with disease." The patent application was filed on Oct. 29, 2009 (12/608,489). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,331.PN.&OS=PN/8,367,331&RS=PN/8,367,331 Written by Kusum Sangma; edited by Anand Kumar.

*** Corning Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Corning, Corning, N.Y., has been assigned a patent (8,367,400) developed by Mark R. Timmins, No. Chelmsford, Mass., for a "culture vessel allowing large in situ scale up." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention, in one aspect, provides a culture vessel which includes a body having at least a first edge at least partially perimetrically bounding the body, and at least a first seal extending from the first edge. The first seal is breachable and fluid-tight, and disposed obliquely to the first edge so as to subtend an acute angle therewith. The first seal separates the body into first and second chambers. Advantageously, with the subject invention, a culture vessel is provided which allows for volume expansion in situ." The patent application was filed on March 23, 2009 (12/408,784). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,400&OS=8,367,400&RS=8,367,400 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Cornell Research Foundation, Sloan-Kettering Institute for Cancer Research Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Cornell Research Foundation, Ithaca, N.Y., and Sloan-Kettering Institute for Cancer Research, New York, have been assigned a patent (8,367,322) developed by six co-inventors for an "accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing." The co-inventors are Francis Barany, New York, Jianzhao Kiu, Boston, Brian W. Kirk, New York, Monib Zirvi, Willingboro, N.J., Norman P. Gerry, Boston, and Philip B. Paty, New York.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention is directed to a method of assembling genomic maps of an organism's DNA or portions thereof. A library of an organism's DNA is provided where the individual genomic segments or sequences are found on more than one clone in the library. Representations of the genome are created, and nucleic acid sequence information is generated from the representations. The sequence information is analyzed to determine clone overlap from a representation. The clone overlap and sequence information from different representations is combined to assemble a genomic map of the organism. Once the genomic map is obtained, genomic sequence information from multiple individuals can be applied to the map and compared with one another to identify single nucleotide polymorphisms. These single nucleotide polymorphisms can be detected, and alleles quantified, by conducting (1) a global PCR amplification which creates a genome representation, and (2) a ligation detection reaction process whose ligation products are captured by hybridization to a support." The patent application was filed on July 17, 2002 (10/198,235). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,322.PN.&OS=PN/8,367,322&RS=PN/8,367,322 Written by Kusum Sangma; edited by Anand Kumar.

*** Invention Science Fund I Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Invention Science Fund I, Bellevue, Wash., has been assigned a patent (8,367,384) developed by five co-inventors for a bone semi-permeable device. The co-inventors are Ed Harlow, Boston, Edward K.Y. Jung, Las Vegas, Robert Langer, Newton, Mass., Eric C. Leuthardt, St. Louis, Lowell L. Wood Jr., Livermore, Wash.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects." The patent application was filed on Oct. 15, 2007 (11/974,852). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,384&OS=8,367,384&RS=8,367,384 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Massachusetts Institute of Technology Assigned Patent for Application of Electrical Stimulation for Functional Tissue Engineering in Vitro and in Vivo ALEXANDRIA, Va., Feb. 9 -- Massachusetts Institute of Technology, Cambridge, Mass., has been assigned a patent (8,367,410) developed by five co-inventors for an "application of electrical stimulation for functional tissue engineering in vitro and in vivo." The co-inventors are Milica Radisic, Cambridge, Mass., Hyoungshin Park, Somerville, Mass., Robert Langer, Newton, Mass., Lisa Freed, Lexington, Mass., and Gordana Vunjak-Novakovic, Belmont, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention provides new methods for the in vitro preparation of bioartificial tissue equivalents and their enhanced integration after implantation in vivo. These methods include submitting a tissue construct to a biomimetic electrical stimulation during cultivation in vitro to improve its structural and functional properties, and/or in vivo, after implantation of the construct, to enhance its integration with host tissue and increase cell survival and functionality. The inventive methods are particularly useful for the production of bioartificial equivalents and/or the repair and replacement of native tissues that contain electrically excitable cells and are subject to electrical stimulation in vivo, such as, for example, cardiac muscle tissue, striated skeletal muscle tissue, smooth muscle tissue, bone, vasculature, and nerve tissue." The patent application was filed on June 21, 2004 (10/872,577). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,410&OS=8,367,410&RS=8,367,410 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Massachusetts Institute of Technology, Brigham and Women's Hospital Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Massachusetts Institute of Technology, Cambridge, Mass., and Brigham and Women's Hospital, Boston, have been assigned a patent (8,367,113) developed by four co-inventors for "polymers for functional particles." The co-inventors are Frank X. Gu, Cambridge, Mass., Benjamin A. Teply, Omaha, Neb., Robert S. Langer, Newton, Mass., and Omid C. Farokhzad, Chestnut Hill, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety. Another aspect of the invention is directed to systems and methods of producing such polymeric conjugates. In some embodiments, a solution containing a polymer is contacted with a liquid, such as an immiscible liquid, to form nanoparticles containing the polymeric conjugate. Other aspects of the invention are directed to methods using such libraries, methods of using or administering such polymeric conjugates, methods of promoting the use of such polymeric conjugates, kits involving such polymeric conjugates, or the like." The patent application was filed on May 15, 2007 (11/803,843). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,113.PN.&OS=PN/8,367,113&RS=PN/8,367,113 Written by Kusum Sangma; edited by Anand Kumar.

*** Brandeis University Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Brandeis University, Waltham, Mass., has been assigned a patent (8,367,325) developed by five co-inventors for a late-PCR. The co-inventors are Lawrence J. Wangh, Auburndale, Mass., Kenneth Pierce, Natick, Mass., Cristina Hartshorn, Needham, Mass., John Rice, Quincy, Mass., and J. Aquiles Sanchez, Framingham, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A non-symmetric polymerise chain reaction (PCR) amplification method employing a limiting primer in low concentration whose concentration-adjusted melting point at least equals, and preferably exceeds, that of the excess primer, the latter in turn not being more than 25.degree. C. below the melting temperature of the amplicon. Assays employing such amplification and labeled hybridization probes, including assays that include a detection step following primer extension or a low-temperature probe, or both. Kits for performing such assays and primer or primer-and-probe sets for performing the foregoing amplifications and assays." The patent application was filed on Feb. 2, 2007 (11/701,428). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,325.PN.&OS=PN/8,367,325&RS=PN/8,367,325 Written by Kusum Sangma; edited by Anand Kumar.

*** Phylonix Pharmaceuticals Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Phylonix Pharmaceuticals, Cambridge, Mass., has been assigned a patent (8,367,364) developed by Patricia McGrath, Cambridge, Mass., and Wen Lin Seng, Westborough, Mass., for "methods of screening an agent for an activity in an isolated eye of a teleost." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention provides methods of screening an agent for an activity in an isolated organ, e.g., eye, from a teleost, e.g., zebrafish. Methods of isolating eyes from zebrafish are provided. Methods of screening an agent for an ocular activity in the isolated eye are provided. Methods of screening an agent for an ocular activity in a model of ocular disease or disorder are provided. Methods of screening an agent for an ocular activity in the isolated eye and for screening the agent for cell death and/or toxic activity in the eye or other organ or tissue are provided. The invention further provides high throughput methods of screening agents for an activity in isolated eyes of zebrafish in multi-well plates." The patent application was filed on Feb. 28, 2011 (13/037,104). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,364&OS=8,367,364&RS=8,367,364 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Helicos Biosciences Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Helicos Biosciences, Cambridge, Mass., has been assigned a patent (8,367,377) developed by five co-inventors for "methods and devices for nucleic acid sequence determination." The co-inventors are Timothy Harris, Ocean County, N.J., Philip Richard Buzby, Brockton, Mass., Mirna Jarosz, Boston, James Joseph Dimeo, Needham, Mass., and Jaime Gill, Marshfield Hills, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Methods of the invention comprise methods and devices for nucleic acid sequence determination. Generally, the invention relates to preparing a substrate for sequencing a target nucleic acid." The patent application was filed on Nov. 16, 2009 (12/618,991). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,377&OS=8,367,377&RS=8,367,377 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Massachusetts Institute of Technology Assigned Patent for Methods and Apparatus for Control of Hydrothermal Nanowire Synthesis ALEXANDRIA, Va., Feb. 9 -- Massachusetts Institute of Technology, Cambridge, Mass., has been assigned a patent (8,367,435) developed by Brian Yichiun Chow, Cambridge, Mass., Jaebum Joo, Medford, Mass., and Manu Prakash, Arlington, Mass., for "methods and apparatus for control of hydrothermal nanowire synthesis." The abstract of the patent published by the U.S. Patent and Trademark Office states: "In exemplary implementations of this invention, hydrothermal synthesis of zinc oxide nanowires is morphologically controlled. Metal complex ions are used to suppress growth in a face-selective manner, by electrostatic crystal growth inhibition. This permits the aspect ratio (height/diameter) of the nanowires to be dynamically tuned over a wide range, from needle-like nanowires that are efficient field emitters to flattened nanowires with a platelet-like shape. The nanowire synthesis is all inorganic and occurs at low temperatures (e.g., <=60.degree. C.). The growth inhibition may be predictively modeled, using speciation plots and treating non-zinc complex ions as ligands. Microfluidic channels may be used for the synthesis, with different solutions flowing down different channels, permitting nanowires with different properties to be synthesized in parallel. This invention may be used to produce field emission devices and nanowire-embedded AC electroluminescent devices, and for in-situ fabrication of spatially complex integrated devices in a polymeric microfluidic system." The patent application was filed on Dec. 3, 2010 (12/960,182). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,367,435&OS=8,367,435&RS=8,367,435 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Exogenesis Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Exogenesis, Billerica, Mass., has been assigned a patent (8,367,092) developed by four co-inventors for a "method for modifying the wettability and/or other biocompatibility characteristics of a surface of a biological material by the application of gas cluster ion beam technology and biological materials made thereby." The co-inventors are Joseph Khoury, Dedham, Mass., Laurence B. Tarrant, Cambridge, Mass., Sean R. Kirkpatrick, Littleton, Mass., and Richard C. Svrluga, Newton, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention provides methods for surgical grafting of a tissue. The method comprises the steps of explanting a graft tissue from a donor, irradiating at least a first portion of the graft tissue with an ion beam, and surgically grafting the graft tissue into a recipient." The patent application was filed on March 11, 2010 (12/722,126). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,092.PN.&OS=PN/8,367,092&RS=PN/8,367,092 Written by Kusum Sangma; edited by Anand Kumar.

*** Boston Scientific Scimed Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Boston Scientific Scimed, Maple Grove, Minn., has been assigned a patent (8,367,096) developed by Robert E. Richard, Wrentham, Mass., and Rudolf Faust, Lexington, Mass., for "polymers having covalently bound therapeutic agents." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Therapeutic polymers are described, which contain at least one polymeric portion and at least one therapeutic agent. The therapeutic agent and the polymeric portion are covalently linked via one or more linkages which hydrolyze in an aqueous environment, for example, one or more linkages selected from an Si--N linkage, an Si--O linkage, and a combination of the same. Other aspects the invention are directed to methods of making the above therapeutic polymers." The patent application was filed on July 19, 2005 (11/184,223). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,096.PN.&OS=PN/8,367,096&RS=PN/8,367,096 Written by Kusum Sangma; edited by Anand Kumar.

*** Atrium Medical Assigned Patent ALEXANDRIA, Va., Feb. 9 -- Atrium Medical, Hudson, N.H., has been assigned a patent (8,367,099) developed by 11 co-inventors for a "perforated fatty acid films." The co-inventors are Steve A. Herweck, Nashua, N.H., Thomas M. Swanick, Hillsborough, N.H., Joseph Ferraro, Londonderry, N.H., Paul Martakos, Pelham, N.H., Lisa Rogers, Londonderry, N.H., Theodore Karwoski, Hollis, N.H., Keith M. Faucher, Nashua, N.H., Philip McNamara, Concord, N.H., Roger Labrecque, Londonderry, N.H., Suzanne Conroy, Dracut, Mass., and Trevor Carlton, Hudson, N.H.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A bio-absorbable stand-alone film is derived at least in part from fatty acids. The bio-absorbable stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. The stand-alone film has one or more perforations or depressions formed therein. Corresponding methods of making the bio-absorbable stand-alone film with one or more perforations or depressions include molding, cutting, carving, puncturing or otherwise suitable methods to create the perforations or depressions in the bio-absorbable stand-alone film. The resulting stand-alone film is bioabsorbable." The patent application was filed on Sept. 22, 2006 (11/525,390). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,367,099.PN.&OS=PN/8,367,099&RS=PN/8,367,099 Written by Kusum Sangma; edited by Anand Kumar.

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