U.S. Patents Awarded to Inventors in California (March 3)

(Targeted News Service Via Acquire Media NewsEdge) Targeted News Service Targeted News Service ALEXANDRIA, Va., March 3 -- The following federal patents were awarded to inventors in California.

*** Vladimir Poponin Assigned Patent ALEXANDRIA, Va., March 3 -- Vladimir Poponin, Costa Mesa, Calif., has been assigned a patent (8,383,416) developed by Vladimir Poponin, Costa Mesa, Calif., for a "microbead optical sensor with layered plasmon structure for enhanced detection of chemical groups by SERS." The abstract of the patent published by the U.S. Patent and Trademark Office states: "An optical sensor and method for use with a visible-light laser excitation beam and a Raman spectroscopy detector, for detecting the presence chemical groups in an analyte applied to the sensor are disclosed. The sensor includes a substrate, a plasmon resonance mirror formed on a sensor surface of the substrate, a plasmon resonance particle layer disposed over the mirror, and an optically transparent dielectric layer about 2-40 nm thick separating the mirror and particle layer. The particle layer is composed of a periodic array of plasmon resonance particles having (i) a coating effective to binding analyte molecules, (ii) substantially uniform particle sizes and shapes in a selected size range between 50-200 nm (ii) a regular periodic particle-to-particle spacing less than the wavelength of the laser excitation beam. The device is capable of detecting analyte with an amplification factor of up to 10.sup.12-10.sup.14, allowing detection of single analyte molecules." The patent application was filed on Jan. 10, 2012 (13/347,566). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,416.PN.&OS=PN/83,83,416&RS=PN/83,83,416 Written by Kusum Sangma; edited by Anand Kumar.

*** Novozymes Assigned Patent ALEXANDRIA, Va., March 3 -- Novozymes, Davis, Calif., has been assigned a patent (8,383,385) developed by six co-inventors for "variants of glycoside hydrolases." The co-inventors are Sarah Teter, Mountain View, Calif., Connie Ward, Hamilton, Mo., Joel Cherry, Winters, Calif., Aubrey Jones, Davis, Calif., Paul Harris, Carnation, Wash., and Jung Yi, Sacramento, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences." The patent application was filed on Jan. 19, 2011 (13/009,524). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,383,385.PN.&OS=PN/8,383,385&RS=PN/8,383,385 Written by Kusum Sangma; edited by Anand Kumar.

*** Novozymes Assigned Patent for Polypeptides having Lipase Activity and Polynucleotides Encoding Same ALEXANDRIA, Va., March 3 -- Novozymes, Bagsvaerd, Denmark, and Novozymes, Davis, Calif., have been assigned a patent (8,383,383) developed by Debbie Yaver, Davis, Calif., and Suzanne Otani, Elk Grove, Calif., for "polypeptides having lipase activity and polynucleotides encoding same." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides." The patent application was filed on Aug. 30, 2012 (13/599,199). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,383,383.PN.&OS=PN/8,383,383&RS=PN/8,383,383 Written by Kusum Sangma; edited by Anand Kumar.

*** HRL Laboratories Assigned Patent ALEXANDRIA, Va., March 3 -- HRL Laboratories, Malibu, Calif., has been assigned a patent (8,383,471) developed by eight co-inventors for a "self aligned sidewall gate GaN HEMT." The co-inventors are Keisuke Shinihara, Thousand Oaks, Calif., Andrea Corrion, Santa Monica, Calif., Miroslav Micovic, Thousand Oaks, Calif., Paul B. Hashimoto, Los Angeles, Shawn D. Burnham, Oxnard, Calif., Hooman Kazemi, Thousand Oaks, Calif., Peter J. Willadsen, Acton, Calif., and Dean C. Regan, Moorpark, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A method of fabricating a GaN HEMT includes growing a first epitaxial layer on a substrate, growing a second epitaxial layer on the first epitaxial layer, growing a third epitaxial layer on the second epitaxial layer, depositing a first dielectric film on the third epitaxial layer, using dielectric films to form a first sidewall dielectric spacer, forming a sidewall gate adjacent the first sidewall dielectric spacer. The sidewall gate may be made to be less than 50 nm in length." The patent application was filed on April 11, 2011 (13/083,916). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,471.PN.&OS=PN/83,83,471&RS=PN/83,83,471 Written by Kusum Sangma; edited by Anand Kumar.

*** SanDisk 3D Assigned Patent ALEXANDRIA, Va., March 3 -- SanDisk 3D, Milpitas, Calif., has been assigned a patent (8,383,478) developed by Scott Brad Herner, San Jose, Calif., and Maitreyee Mahajani, Saratoga, Calif., for a "high-density nonvolatile memory and methods of making the same." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Nonvolatile memory cells and methods of forming the same are provided, the methods including forming a first conductor at a first height above a substrate; forming a first pillar-shaped semiconductor element above the first conductor, wherein the first pillar-shaped semiconductor element comprises a first heavily doped layer of a first conductivity type, a second lightly doped layer above and in contact with the first heavily doped layer, and a third heavily doped layer of a second conductivity type above and in contact with the second lightly doped layer, the second conductivity type opposite the first conductivity type; forming a first dielectric antifuse above the third heavily doped layer of the first pillar-shaped semiconductor element; and forming a second conductor above the first dielectric antifuse." The patent application was filed on Aug. 1, 2011 (13/195,518). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,478.PN.&OS=PN/83,83,478&RS=PN/83,83,478 Written by Kusum Sangma; edited by Anand Kumar.

*** Intermolecular Assigned Patent ALEXANDRIA, Va., March 3 -- Intermolecular, San Jose, Calif., has been assigned a patent (8,383,430) developed by six co-inventors for "methods of combinatorial processing for screening multiple samples on a semiconductor substrate." The co-inventors are Guarav Verma, San Jose, Calif., Tony P. Chiang, Campbell, Calif., Imran Hashim, Saratoga, Calif., Sandra G. Malhotra, San Jose, Calif., Prashant B. Phatak, San Jose, Calif., and Kurt H. Weiner, San Jose, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "In embodiments of the current invention, methods of combinatorial processing and a test chip for use in these methods are described. These methods and test chips enable the efficient development of materials, processes, and process sequence integration schemes for semiconductor manufacturing processes. In general, the methods simplify the processing sequence of forming devices or partially formed devices on a test chip such that the devices can be tested immediately after formation. The immediate testing allows for the high throughput testing of varied materials, processes, or process sequences on the test chip. The test chip has multiple site isolated regions where each of the regions is varied from one another and the test chip is designed to enable high throughput testing of the different regions." The patent application was filed on Feb. 17, 2012 (13/399,719). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,430.PN.&OS=PN/83,83,430&RS=PN/83,83,430 Written by Kusum Sangma; edited by Anand Kumar.

*** E.I. du Pont de Nemours Assigned Patent ALEXANDRIA, Va., March 3 -- E.I. du Pont de Nemours, Wilmington, Del., has been assigned a patent (8,383,455) developed by Ed Sundaram Ramakrishnan, Spring, Texas, and Shiva Prakash, Santa Barbara, Calif., for an "electronic device including an organic active layer and process for forming the electronic device." The abstract of the patent published by the U.S. Patent and Trademark Office states: "An electronic device can include an organic active layer and an electrode. In one aspect, the electrode can further include a first layer that is conductive, and a second layer that is conductive. The second layer can include a defect extending at least partly through a thickness of the second conductive layer. The electrode can also include a third layer lying within and substantially filling the defect, wherein each of the second and third layers includes a same metallic element. In another aspect, a process for forming an electronic device can include forming an organic active layer and forming a first layer that is conductive and is part of an electrode. The process can also include forming a second layer and exposing the second layer to a first plasma to form a first compound from the second layer." The patent application was filed on March 19, 2012 (13/423,797). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,455.PN.&OS=PN/83,83,455&RS=PN/83,83,455 Written by Kusum Sangma; edited by Anand Kumar.

*** University of California Assigned Patent ALEXANDRIA, Va., March 3 -- The University of California, Oakland, Calif., has been assigned a patent (8,383,423) developed by four co-inventors for a "peptide-coated nanoparticles with graded shell compositions." The co-inventors are Shimon Weiss, Los Angeles, James M. Tsay, Los Angeles, Fabien Pinaud, Los Angeles, and Soren Doose, Bielefeld, Germany.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A peptide-coated nanoparticle that includes a nanocrystal surrounded by a graded shell that is composed of at least two different semiconductor molecules. At least one peptide is attached to the surface of the graded shell to render the nanoparticle biocompatible. The nanocrystal core and graded shell are optionally annealed with ultra violet radiation prior to and/or after attachment of the peptide(s)." The patent application was filed on March 29, 2011 (13/074,209). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,423.PN.&OS=PN/83,83,423&RS=PN/83,83,423 Written by Kusum Sangma; edited by Anand Kumar.

*** SanDisk Technologies Assigned Patent ALEXANDRIA, Va., March 3 -- SanDisk Technologies, Plano, Texas, has been assigned a patent (8,383,479) developed by six co-inventors for an "integrated nanostructure-based non-volatile memory fabrication." The co-inventors are Vinod Robert Purayath, Santa Clara, Calif., James K. Kai, Santa Clara, Calif., Masaaki Higashitani, Cupertino, Calif., Takashi Orimoto, Sunnyvale, Calif., George Matamis, San Jose, Calif., and Henry Chien, San Jose, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Nanostructure-based charge storage regions are included in non-volatile memory devices and integrated with the fabrication of select gates and peripheral circuitry. One or more nanostructure coatings are applied over a substrate at a memory array area and a peripheral circuitry area. Various processes for removing the nanostructure coating from undesired areas of the substrate, such as target areas for select gates and peripheral transistors, are provided. One or more nanostructure coatings are formed using self-assembly based processes to selectively form nanostructures over active areas of the substrate in one example. Self-assembly permits the formation of discrete lines of nanostructures that are electrically isolated from one another without requiring patterning or etching of the nanostructure coating." The patent application was filed on July 20, 2010 (12/840,081). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,479.PN.&OS=PN/83,83,479&RS=PN/83,83,479 Written by Kusum Sangma; edited by Anand Kumar.

*** Stion Assigned Patent ALEXANDRIA, Va., March 3 -- Stion, San Jose, Calif., has been assigned a patent (8,383,450) developed by Robert D. Wieting, San Jose, Calif., for a "large scale chemical bath system and method for cadmium sulfide processing of thin film photovoltaic materials." The abstract of the patent published by the U.S. Patent and Trademark Office states: "A method for forming a thin film photovoltaic material. The method includes providing a plurality of substrates. Each of the substrates has a surface region, an overlying first electrode material, an absorber material including at least a copper species, an indium species, and a selenium species. The method immerses the plurality of substrates in an aqueous solution including an ammonia species, a cadmium species, and a organosulfur (for example, thiourea) species in a bath to form a cadmium sulfide window material having a thickness of less than about 200 Angstroms overlying the absorber material. The aqueous solution is maintained at a temperature ranging from about 50 to about 60 Degrees Celsius. The plurality of substrates having at least the absorber material and the window layer are removed from the aqueous solution. The aqueous solution is further subjected to a filter process to substantially remove one or more particles greater than about 5 microns." The patent application was filed on Sept. 29, 2009 (12/569,490). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,450.PN.&OS=PN/83,83,450&RS=PN/83,83,450 Written by Kusum Sangma; edited by Anand Kumar.

*** Applied Isotope Technologies, Lineman Assigned Patent ALEXANDRIA, Va., March 3 -- Applied Isotope Technologies, Pittsburgh, and David Lineman, Greenville, Pa., have been assigned a patent (8,383,420) developed by four co-inventors for a "solid phase and catalyzed enabled automated isotope dilution and speciated isotope dilution mass spectrometry." The co-inventors are Howard M. Kingston, Pittsburgh, Mizanur Rahman, Cheswick, Pa., David Lineman, Greenville, Pa., and Mehmet Pamukcu, Sunnyvale, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A method for the equilibration of enriched isotope species and natural isotope species prior to mass spectrometric analysis using solid phase and/or microwave isotope ratio equilibration and measurement." The patent application was filed on Dec. 7, 2007 (11/952,471). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,420.PN.&OS=PN/83,83,420&RS=PN/83,83,420 Written by Kusum Sangma; edited by Anand Kumar.

*** Codexis Assigned Patent ALEXANDRIA, Va., March 3 -- Codexis, Redwood City, Calif., has been assigned a patent (8,383,382) developed by eight co-inventors for a "variant LovD polypeptides and their uses." The co-inventors are Lynne Gilson, Redwood City, Calif., Steven James Collier, The Galen, Singapore, Joly Sukumaran, The Galen, Singapore, Wan Lin Yeo, The Galen, Singapore, Oscar Alvizo, Redwood City, Calif., Ee Ling Teo, The Galen, Singapore, Robert John Wilson, The Galen, Singapore, and Junye Xu, The Galen, Singapore.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound." The patent application was filed on Sept. 24, 2010 (12/890,134). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,383,382.PN.&OS=PN/8,383,382&RS=PN/8,383,382 Written by Kusum Sangma; edited by Anand Kumar.

*** AQT Solar Assigned Patent ALEXANDRIA, Va., March 3 -- AQT Solar, Sunnyvale, Calif., has been assigned a patent (8,383,451) developed by Brian Josef Bartholomeusz, Palo Alto, Calif., and Michael Bartholomeusz, Phoenix, for a "deposition of photovoltaic thin films by plasma spray deposition." The abstract of the patent published by the U.S. Patent and Trademark Office states: "In particular embodiments, a method is described for depositing thin films, such as those used in forming a photovoltaic cell or device. In a particular embodiment, the method includes providing a substrate suitable for use in a photovoltaic device and plasma spraying one or more layers over the substrate, the grain size of the grains in each of the one or more layers being at least approximately two times greater than the thickness of the respective layer." The patent application was filed on March 2, 2010 (12/716,024). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,451.PN.&OS=PN/83,83,451&RS=PN/83,83,451 Written by Kusum Sangma; edited by Anand Kumar.

*** California Institute of Technology Assigned Patent ALEXANDRIA, Va., March 3 -- California Institute of Technology, Pasadena, Calif., has been assigned a patent (8,383,425) developed by four co-inventors for a "method and compositions for the detection of protein glycosylation." The co-inventors are Linda Hsieh-Wilson, San Marino, Calif., Nelly Khidekel, Pasadena, Calif., Hwan-Ching Tai, Pasadena, Calif., and Sabine Arndt, Dortmund, Germany.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with post-translational glycosylations. The methods can be used to detect O-GlcNAc posttranslational modifications on proteins on which such modifications were undetectable using other techniques. In one embodiment, the method exploits the ability of an engineered mutant of .beta.-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling detection of the modified protein. The approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Further, the preferred embodiments can be used for detection of certain disease states, such as cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes." The patent application was filed on Oct. 21, 2010 (12/909,402). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,425.PN.&OS=PN/83,83,425&RS=PN/83,83,425 Written by Kusum Sangma; edited by Anand Kumar.

*** University of California Assigned Patent for Micro-bubble Plate for Patterning Biological and Non-biological Materials ALEXANDRIA, Va., March 3 -- The University of California, Oakland, Calif., has been assigned a patent (8,383,378) developed by five co-inventors for a "micro-bubble plate for patterning biological and non-biological materials." The co-inventors are Yuli Wang, Irvine, Calif., Mark Bachman, Irvine, Calif., Christopher E. Sims, Irvine, Calif., Guann-Pyng Li, Irvine, Calif., and Nancy Allbritton, Irvine, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment of the present invention include a method for placing materials on the plate at pre-determined locations through the use of trapped gas to prevent materials from collecting at unwanted regions. The plate has great utility for plating cells and tissues at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate with coatings at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micro-mechanical structures--where the structures may be formed from living or non-living material, tissue or non-tissue, organic or inorganic, and the like." The patent application was filed on Oct. 9, 2006 (11/539,695). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,383,378.PN.&OS=PN/8,383,378&RS=PN/8,383,378 Written by Kusum Sangma; edited by Anand Kumar.

*** Stanford University Assigned Patent ALEXANDRIA, Va., March 3 -- Stanford University, Palo Alto, Calif., has been assigned a patent (8,383,349) developed by four co-inventors for a "bone morphogenetic protein antagonist and uses thereof." The co-inventors are Hanson Zhen, Stanford, Calif., Julie Sneddon, Palo Alto, Calif., Patrick O. Brown, Stanford, Calif., and Anthony Oro, Stanford, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to the use of proteins that are differentially expressed in tumor associated stromal cells, as compared to normal stromal, as biomolecular targets for tumor treatment therapies. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention." The patent application was filed on March 13, 2008 (12/075,944). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,349.PN.&OS=PN/83,83,349&RS=PN/83,83,349 Written by Kusum Sangma; edited by Anand Kumar.

*** Abraxis BioScience Assigned Patent ALEXANDRIA, Va., March 3 -- Abraxis BioScience, Los Angeles, has been assigned a patent (8,383,358) developed by Vuong Trieu, Calabasas, Calif., Neil Desai, Los Angeles, and Daniel Knauer, Costa Mesa, Calif., for a "use of 2 anti-SPARC antibodies to predict response to melanoma chemotherapy." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention provides anti-SPARC antibody-based techniques for predicting a response to chemotherapy." The patent application was filed on May 28, 2010 (12/790,231). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,358.PN.&OS=PN/83,83,358&RS=PN/83,83,358 Written by Kusum Sangma; edited by Anand Kumar.

*** Institut National de la Sante et de la Recherche Medicale (INSERM), University of California Assigned Patent ALEXANDRIA, Va., March 3 -- Institut National de la Sante et de la Recherche Medicale (INSERM), Paris, and the University of California, Oakland, Calif., have been assigned a patent (8,383,355) developed by four co-inventors for a "combination of sPLA2 type IIA mass and OXPL/APOB cardiovascular risk factors for the diagnosis/prognosis of a cardiovascular disease/event." The co-inventors are Ziad Mallat, Paris, Alain Tedgui, Paris, Sotirios Tsimikas, La Jolla, Calif., and Joseph Witztum, La Jolla, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention related to a method of identifying a subject having or at risk of having or developing a cardiovascular disease and/or a cardiovascular event, comprising: --measuring, in a sample obtained from said subject, at least two cardiovascular risk factors: a) sPLA2 type HA mass and b) oxidized phospholipids on apolipoprotein B-IOO particles (OxPL/apoB), --combining said measurements, the combined value of sPLA2 type HA mass and OxPL/apoB being indicative of having or a risk of having or developing a cardiovascular disease and/or cardiovascular event." The patent application was filed on Sept. 27, 2012 (13/498,208). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,355.PN.&OS=PN/83,83,355&RS=PN/83,83,355 Written by Kusum Sangma; edited by Anand Kumar.

*** AMBRX Assigned Patent ALEXANDRIA, Va., March 3 -- AMBRX, La Jolla, Calif., has been assigned a patent (8,383,365) developed by eight co-inventors for "methods of making FGF-21 mutants comprising non-naturally encoded phenylalanine derivatives." The co-inventors are Thomas P. Cujec, San Diego, Roberto Mariani, San Diego, Anna-Maria A. Hays Putnam, San Diego, William M. Keefe, West Hollywood, Calif., Nick Knudsen, San Diego, Lillian Skidmore (Nee Ho), San Diego, Jason Pinkstaff, Encinitas, Calif., and Vadim Kraynov, San Diego.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Modified FGF-21 polypeptides and uses thereof are provided." The patent application was filed on March 18, 2011 (13/051,953). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,383,365.PN.&OS=PN/8,383,365&RS=PN/8,383,365 Written by Kusum Sangma; edited by Anand Kumar.

*** Osmetch Technology Assigned Patent ALEXANDRIA, Va., March 3 -- Osmetch Technology, Pasadena, Calif., has been assigned a patent (8,383,356) developed by Stephen D. O'Connor, Pasadena, Calif., Jon Faiz Kayyem, Pasadena, Calif., and Thomas J. Meade, Wilmette, Ill., for an "electronic methods for the detection of analytes." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques." The patent application was filed on Feb. 3, 2012 (13/366,068). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,356.PN.&OS=PN/83,83,356&RS=PN/83,83,356 Written by Kusum Sangma; edited by Anand Kumar.

*** Pacific Biosciences of California Assigned Patent ALEXANDRIA, Va., March 3 -- Pacific Biosciences of California, Menlo Park, Calif., has been assigned a patent (8,383,369) developed by nine co-inventors for an "intermittent detection during analytical reactions." The co-inventors are Kenneth Mark Maxham, Redwood City, Calif., Jon Sorenson, Alameda, Calif., John Eid, San Francisco, Patrick Marks, San Francisco, Kevin Travers, Santa Clara, Calif., Donald Gray, San Francisco, Robin Emig, Belmont, Calif., Mark Chaisson, San Francisco, and Benjamin Flusberg, Palo Alto, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Methods, devices, and systems for performing intermittent detection during analytical reactions are provided. Such methods facilitate collection of reaction data from disparate reaction times. Further, such methods are useful for reducing photo-induced damage of one or more reactants in an illuminated analytical reaction at a given reaction time. In preferred embodiments, the reaction mixture is subjected to at least one illuminated and non-illuminated period and allowed to proceed such that the time in which the reaction mixture is illuminated is less than a photo-induced damage threshold period." The patent application was filed on Sept. 16, 2009 (12/561,221). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,383,369.PN.&OS=PN/8,383,369&RS=PN/8,383,369 Written by Kusum Sangma; edited by Anand Kumar.

*** Danisco USA Assigned Patent ALEXANDRIA, Va., March 3 -- Danisco USA, Palo Alto, Calif., has been assigned a patent (8,383,366) developed by four co-inventors for an "enhanced protein expression in Bacillus." The co-inventors are Eugenio Ferrari, Palo Alto, Calif., Carole Harbison, Palo Alto, Calif., M. Harunur Rashid, Palo Alto, Calif., and Walter Weyler, Palo Alto, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and preferably wherein one or more chromosomal genes have been deleted from the Bacillus chromosome. In some further embodiments, one or more indigenous chromosomal regions have been deleted from a corresponding wild-type Bacillus host chromosome." The patent application was filed on Jan. 23, 2012 (13/356,572). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,383,366.PN.&OS=PN/8,383,366&RS=PN/8,383,366 Written by Kusum Sangma; edited by Anand Kumar.

*** Abbott Diabetes Care Assigned Patent ALEXANDRIA, Va., March 3 -- Abbott Diabetes Care, Alameda, Calif., has been assigned a patent (8,383,361) developed by four co-inventors for a "method for determining analyte concentration in biological fluid using electrochemical sensor." The co-inventors are Adam Heller, Austin, Texas, Benjamin J. Feldman, Oakland, Calif., Nicolas Mano, Austin, Texas, and Yueh-Lin Loo, Lawrenceville, N.J.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme. The polymer matrix may be hydrated, and the absorbed water may make it permeable to, for example, glucose. The polyaniline may be polyaniline itself or a substituted polyaniline; the water-soluble crosslinker may be poly(ethylene glycol)diglycidyl ether, and the redox enzyme may be glucose oxidase. The polymer matrix may be produced by co-crosslinking (1) an adduct of an electrically conductive polymer and a polymer acid; (2) a water-soluble crosslinker; and (3) a redox enzyme in a single step at an about neutral pH, curing by drying. After hydration, the crosslinked polymer matrix may form a 3-dimensional glucose-permeable bioelectrocatalyst, catalyzing the electrooxidation of glucose." The patent application was filed on Dec. 14, 2011 (13/326,071). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,361.PN.&OS=PN/83,83,361&RS=PN/83,83,361 Written by Kusum Sangma; edited by Anand Kumar.

*** Codexis Assigned Patent ALEXANDRIA, Va., March 3 -- Codexis, Redwood City, Calif., has been assigned a patent (8,383,346) developed by seven co-inventors for a "combined automated parallel synthesis of polynucleotide variants." The co-inventors are Jeffrey Colbeck, Menlo Park, Calif., Benjamin Mijts, Belmont, Calif., Lorraine Joan Giver, Sunnyvale, Calif., Richard J. Fox, Kirkwood, Mo., Vesna Mitchell, San Jose, Calif., Bumshik Robert Pak, Fremont, Calif., and Lynne Gilson, Encinitas, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide." The patent application was filed on Sept. 18, 2009 (12/562,988). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,346.PN.&OS=PN/83,83,346&RS=PN/83,83,346 Written by Kusum Sangma; edited by Anand Kumar.

*** University of California Assigned Patent for Methods of Diagnosing and Treating Autism ALEXANDRIA, Va., March 3 -- The University of California, Oakland, Calif., has been assigned a patent (8,383,360) developed by Judy Van de Water, Capay, Calif., and Daniel Braunschweig, Davis, Calif., for "methods of diagnosing and treating autism." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention provides diagnostic methods for determining the risk of developing an autism spectrum disorder (ASD) in a fetus or child by detecting in a biological sample from the mother antibodies that bind to one or more biomarkers selected from the group consisting of lactate dehydrogenase (LDH), guanine deaminase (GDA), collapsin response mediator protein 1 (CRMP1), stress-induced phosphoprotein 1 (STIP1), alpha subunit of the barbed-end actin binding protein Cap Z (CAPZA2), Y Box Binding Protein 1 (YBX1), eukaryotic translation and elongation factor 1A1 (EEF1A1), microtubule-associated protein Tau (MAPT), dihydropyrimidinase-like protein 2 (DPYSL2), dynamin 1-like protein (DNM1L), radixin (RDX), moesin (MSN), and ezrin (EZR). The invention further provides methods of preventing or reducing the risk of a fetus or child developing an ASD by administering to the mother an agent that blocks the binding of maternal antibodies to the one or more fetal biomarkers listed above or by removing from the mother antibodies that bind to the one or more fetal biomarkers." The patent application was filed on Aug. 12, 2010 (12/855,558). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,360.PN.&OS=PN/83,83,360&RS=PN/83,83,360 Written by Kusum Sangma; edited by Anand Kumar.

*** Stanford University Assigned Patent for Precircle Probe Nucleic Acid Amplification Methods ALEXANDRIA, Va., March 3 -- Stanford University, Stanford, Calif., has been assigned a patent (8,383,348) developed by six co-inventors for a "precircle probe nucleic acid amplification methods." The co-inventors are Thomas D. Willis, San Francisco, Paul Hardenbol, Los Altos, Calif., Maneesh Jain, Menlo Park, Calif., Viktor Stolc, Cupertino, Calif., Mostafa Ronaghi, Palo Alto, Calif., and Ronald W. Davis, Palo Alto, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified." The patent application was filed on Aug. 9, 2011 (13/206,120). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,83,348.PN.&OS=PN/83,83,348&RS=PN/83,83,348 Written by Kusum Sangma; edited by Anand Kumar.

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