U.S. Patents Awarded to Inventors in North Carolina (March 16)

(Targeted News Service Via Acquire Media NewsEdge) Targeted News Service Targeted News Service ALEXANDRIA, Va., March 16 -- The following federal patents were awarded to inventors in North Carolina.

*** EICES Research Assigned Patent ALEXANDRIA, Va., March 16 -- EICES Research, Cary, N.C., has been assigned a patent (8,394,439) developed by Dimitrios P. Karabinis, Cary, N.C., for a "mixing first and second substances responsive to opening of a container." The abstract of the patent published by the U.S. Patent and Trademark Office states: "This invention relates to containers that include at least one sub-container and to methods and/or systems for mixing first and second substances responsive to opening of the containers and the at least one sub-container that is included therein. The invention advantageously provides methods, systems, containers, sub-containers, seals and/or tethers that may be used in storing first and second substances in an unmixed state, until it is desired to mix the first and second substances just before utilization thereof." The patent application was filed on Sept. 21, 2009 (12/563,393). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,394,439.PN.&OS=PN/8,394,439&RS=PN/8,394,439 Written by Kusum Sangma; edited by Anand Kumar.

*** GM Global Technology Operations Assigned Patent for Lithium Salts of Fluorinated Borate Esters for Lithium-ion Batteries ALEXANDRIA, Va., March 16 -- GM Global Technology Operations, Detroit, has been assigned a patent (8,394,539) developed by four co-inventors for a "lithium salts of fluorinated borate esters for lithium-ion batteries." The co-inventors are Olt E. Geiculescu, Easley, S.C., Ion C. Halalay, Grosse Pointe Park, Mich., Darryl D. Desmarteau, Seneca, S.C., and Stephen E. Creager, Clemson, S.C.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Lithium salts with fluorinated chelated orthoborate anions are prepared and used as electrolytes or electrolyte additives in lithium-ion batteries. The lithium salts have two chelate rings formed by the coordination of two bidentate ligands to a single boron atom. In addition, each chelate ring has two oxygen atoms bonded to one boron atom, methylene groups bonded to the two oxygen atoms, and one or more fluorinated carbon atoms bonded to and forming a cyclic bridge between the methylene groups." The patent application was filed on June 21, 2012 (13/528,899). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,394,539.PN.&OS=PN/8,394,539&RS=PN/8,394,539 Written by Kusum Sangma; edited by Anand Kumar.

*** Valspar Sourcing Assigned Patent ALEXANDRIA, Va., March 16 -- Valspar Sourcing, Minneapolis, has been assigned a patent (8,394,496) developed by four co-inventors for a "single pack low temperature bake coating composition." The co-inventors are Michael D. Foster, Jamestown, N.C., Nellie M. Moretz, Archdale, N.C., George A. Sparks, High Point, N.C., and Willette D. Crosby, High Point, N.C.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Substrates prone to heat distortion may be coated with a coating composition containing chlorinated polyolefin-modified acrylic latex emulsion, polyurethane dispersion, non-gelling self-crosslinking acrylic emulsion, and glycol-based solvent. The coating composition contains sufficient non-gelling self-crosslinking acrylic emulsion and glycol-based solvent so that a 0.1 mm wet thickness layer of the coating composition will form a tack-free film when heated at 65.degree. C. for fifteen minutes, and the glycol-based solvent is selected so that the coating composition is shelf stable." The patent application was filed on June 6, 2007 (12/663,267). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=8,394,496.PN.&OS=PN/8,394,496&RS=PN/8,394,496 Written by Kusum Sangma; edited by Anand Kumar.

*** ATI Properties Assigned Patent ALEXANDRIA, Va., March 16 -- ATI Properties, Albany, Ore., has been assigned a patent (8,394,210) developed by four co-inventors for "nickel-base alloys and articles made therefrom." The co-inventors are Wei-Di Cao, Charlotte, N.C., Richard L. Kennedy, Monroe, N.C., Michael M. Antony, Monroe, N.C., and John W. Smythe, Charlotte, N.C.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A nickel-base alloy having favorable toughness and thermal fatigue resistance comprises, in weight percentages based on total alloy weight: 9 to 12 chromium; 25 to 35 iron; 1 to 3 molybdenum; 3.0 to 5.5 niobium; 0.2 to 2.0 aluminum; 0.3 to 3.0 titanium; less than 0.10 carbon; no more than 0.01 boron; nickel; and incidental impurities. Also disclosed are die casting dies, other tooling, and other articles of manufacture made from or comprising the nickel-base alloy." The patent application was filed on May 5, 2011 (13/101,207). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=83,94,210.PN.&OS=PN/83,94,210&RS=PN/83,94,210 Written by Amal Ahmed; edited by Jaya Anand.

*** Merial, Biolex Therapeutics Assigned Patent ALEXANDRIA, Va., March 16 -- Merial, Duluth, Ga., and Biolex Therapeutics, Pittsboro, N.C., have been assigned a patent (8,394,384) developed by four co-inventors for a "recombinant avian influenza vaccine and uses thereof." The co-inventors are Xuan Guo, Suwanee, Ga., Michel Bublot, Chaponost, France, Joyce A. Pritchard, Gainesville, Ga., and Lynn F. Dickey, Cary, N.C.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention encompasses influenza vaccines, in particular avian influenza vaccines. The vaccine may be a subunit vaccine based on the hemagglutinin of influenza. The hemagglutinin may be expressed in plants including duckweed. The invention also encompasses recombinant vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals against influenza. It encompasses also a vaccination regimen compatible with the DIVA strategy, including a prime-boost scheme using vector and subunit vaccines." The patent application was filed on Nov. 30, 2009 (12/628,085). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,384&OS=8,394,384&RS=8,394,384 Written by Arpi Sharma; edited by Anand Kumar.

*** Albert Einstein College of Medicine of Yeshiva University Assigned Patent ALEXANDRIA, Va., March 16 -- Albert Einstein College of Medicine of Yeshiva University, Bronx, N.Y., has been assigned a patent (8,394,388) developed by four co-inventors for a "mycobacterial mutants affecting host apoptosis." The co-inventors are William R. Jacobs Jr., Pelham, N.Y., Steven A. Porcelli, Bronx, N.Y., Volker Briken, Burtonsville, Md., and Miriam Braunstein, Chapel Hill, N.C.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally provided are isolated and purified nucleic acids comprising a recombinant nlaA gene or a recombinant nuoG gene. Further provided are methods of inducing an immune response in a mammal and methods of making a recombinant mycobacterium using the nlaA gene or the nuoG gene." The patent application was filed on Jan. 12, 2006 (11/794,506). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,388&OS=8,394,388&RS=8,394,388 Written by Arpi Sharma; edited by Anand Kumar.

*** Metabolon, Duke University Assigned Patent ALEXANDRIA, Va., March 16 -- Metabolon, Durham, N.C., and Duke University, Durham, N.C., have been assigned a patent (8,394,354) developed by seven co-inventors for "biomarkers for depression and methods using the same." The co-inventors are Lisa A. Paige, Hillsborough, N.C., Matthew W. Mitchell, Durham, N.C., Anne Evans, Durham, N.C., Don Harvan, Durham, N.C., David Carl Steffens, Durham, N.C., K. Ranga R. Krishnan, Chapel Hill, N.C., and Rima Kaddurah-Daouk, Belmont, Mass.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention provides various biomarkers of depression. The present invention also provides various methods of using the biomarkers, including methods for diagnosis of depression, methods of determining predisposition to depression, methods of monitoring progression/regression of depression, methods of assessing efficacy of compositions for treating depression, methods of screening compositions for activity in modulating biomarkers of depression, methods of treating depression, as well as other methods based on biomarkers of depression." The patent application was filed on May 8, 2007 (12/300,000). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,354&OS=8,394,354&RS=8,394,354 Written by Arpi Sharma; edited by Anand Kumar.

*** Aerie Pharmaceuticals Assigned Patent ALEXANDRIA, Va., March 16 -- Aerie Pharmaceuticals, Research Triangle Park, N.C., has been assigned a patent (8,394,826) developed by Mitchell A. deLong, Chapel Hill, N.C., Jill Marie Sturdivant, Chapel Hill, N.C., and Susan M. Royalty, Cary, N.C., for "dual mechanism inhibitors for the treatment of disease." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved." The patent application was filed on Jan. 27, 2010 (12/694,965). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,826&OS=8,394,826&RS=8,394,826 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Acetylon Pharmaceuticals Assigned Patent ALEXANDRIA, Va., March 16 -- Acetylon Pharmaceuticals, Boston, has been assigned a patent (8,394,810) developed by seven co-inventors for "reverse amide compounds as protein deacetylase inhibitors and methods of use thereof." The co-inventors are John H. van Duzer, Georgetown, Mass., Ralph Mazitschek, Arlington, Mass., Walter Ogier, Winchester, Mass., James E. Bradner, Cambridge, Mass., Guoxiang Huang, Kernersville, N.C., Dejian Xie, Shanghai, China, and Nan Yu, Shanghai, China.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6." The patent application was filed on Jan. 21, 2011 (13/010,974). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,810&OS=8,394,810&RS=8,394,810 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Advanced Liquid Logic Assigned Patent ALEXANDRIA, Va., March 16 -- Advanced Liquid Logic, Research Triangle Park, N.C., has been assigned a patent (8,394,641) developed by Theodore Winger, Morrisville, N.C., for a "method of hydrolyzing an enzymatic substrate." The abstract of the patent published by the U.S. Patent and Trademark Office states: "The invention is directed to droplet actuator devices and assay methods. The method may include immobilization of the enzymatic substrate including forming an inclusion complex with the substrate within an aqueous environment in contact with an oil." The patent application was filed on Nov. 29, 2011 (13/305,820). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,641&OS=8,394,641&RS=8,394,641 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** University of Illinois Assigned Patent for Printable Semiconductor Structures and Related Methods of Making and Assembling ALEXANDRIA, Va., March 16 -- The University of Illinois, Urbana, Ill., has been assigned a patent (8,394,706) developed by 10 co-inventors for "printable semiconductor structures and related methods of making and assembling." The co-inventors are Ralph G. Nuzzo, Champaign, Ill., John A. Rogers, Champaign, Ill., Etienne Menard, Durham, N.C., Keon Jae Lee, Tokyo, Dahl-Young Khang, Urbana, Ill., Yugang Sun, Westmont, Ill., Matthew Meitl, Raleigh, N.C., Zhengtao Zhu, Rapid City, S.D., Heung Cho Ko, Urbana, Ill., and Shawn Mack, Goleta, Calif.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention provides a high yield pathway for the fabrication, transfer and assembly of high quality printable semiconductor elements having selected physical dimensions, shapes, compositions and spatial orientations. The compositions and methods of the present invention provide high precision registered transfer and integration of arrays of microsized and/or nanosized semiconductor structures onto substrates, including large area substrates and/or flexible substrates. In addition, the present invention provides methods of making printable semiconductor elements from low cost bulk materials, such as bulk silicon wafers, and smart-materials processing strategies that enable a versatile and commercially attractive printing-based fabrication platform for making a broad range of functional semiconductor devices." The patent application was filed on Oct. 11, 2011 (13/270,954). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,706&OS=8,394,706&RS=8,394,706 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** Molsoft, New York University Assigned Patent ALEXANDRIA, Va., March 16 -- Molsoft, La Jolla, Calif., and New York University, New York, have been assigned a patent (8,394,811) developed by eight co-inventors for "hydrazide compounds as thyroid hormone receptor modulators and uses thereof." The co-inventors are Herbert H. Samuels, New Rochelle, N.Y., Ruben Abagyan, La Jolla, Calif., Matthieu Schapira, Toronto, Maxim Totrov, San Diego, Bruce M. Raaka, Rockville, Md., Stephen R. Wilson, Danville, Va., Li Fan, Cambridge, Mass., and Zhiguo Zhou, Winston Salem, N.C.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "A method of identification of compounds that modulate thyroid hormone activity, and the use of such compounds and compositions thereof for such purposes are disclosed. The compounds may be selected from the group consisting of: ##STR00001## The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant thyroid hormone activity, such as hyperthyroidism and thyrotoxicosis." The patent application was filed on April 18, 2008 (12/450,922). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,811&OS=8,394,811&RS=8,394,811 Written by Satyaban Rath; edited by Hemanta Panigrahi.

*** E.I. du Pont de Nemours Assigned Patent ALEXANDRIA, Va., March 16 -- E.I. du Pont de Nemours, Wilmington, Del., has been assigned a patent (8,394,297) developed by four co-inventors for a "method of manufacture of semiconductor device and conductive compositions used therein." The co-inventors are Yueli Wang, Cary, N.C., Richard John Sheffield Young, Somerset, United Kingdom, Alan Frederick Carroll, Raleigh, N.C., and Kenneth Warren Hang, Hillsborough, N.C.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present invention is directed to a thick film conductive composition comprising: (a) electrically conductive silver powder; (b) Zn-containing additive wherein the particle size of said zinc-containing additive is in the range of 7 nanometers to less than 100 nanometers; (c) glass frit wherein said glass frit has a softening point in the range of 300 to 600.degree. C.; dispersed in (d) organic medium. The present invention is further directed to a semiconductor device and a method of manufacturing a semiconductor device from a structural element composed of a semiconductor having a p-n junction and an insulating film formed on a main surface of the semiconductor comprising the steps of (a) applying onto said insulating film the thick film composition as describe above; and (b) firing said semiconductor, insulating film and thick film composition to form an electrode." The patent application was filed on March 8, 2011 (13/042,770). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,297&OS=8,394,297&RS=8,394,297 Written by Arpi Sharma; edited by Anand Kumar.

*** Duke University Assigned Patent ALEXANDRIA, Va., March 16 -- Duke University, Durham, N.C., has been assigned a patent (8,394,249) developed by Michael G. Pollack, Durham, N.C., Vamsee K. Pamula, Durham, N.C., and Richard B. Fair, Durham, N.C., for "methods for manipulating droplets by electrowetting-based techniques." The abstract of the patent published by the U.S. Patent and Trademark Office states: "Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements, wherein the droplet is disposed on a first one of the electrodes, and the droplet at least partially overlaps a second one of the electrodes and an intervening one of the reference elements disposed between the first and second electrodes. The methods further include activating the first and second electrodes to spread at least a portion of the droplet across the second electrode and deactivating the first electrode to move the droplet from the first electrode to the second electrode." The patent application was filed on June 30, 2009 (12/494,927). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,249&OS=8,394,249&RS=8,394,249 Written by Arpi Sharma; edited by Anand Kumar.

*** Biomet Manufacturing Assigned Patent ALEXANDRIA, Va., March 16 -- Biomet Manufacturing, Warsaw, Ind., has been assigned a patent (8,394,103) developed by four co-inventors for a "method and apparatus for orthopedic fixation." The co-inventors are Joseph Michael O'Reilly, South Plainfield, N.J., Philip Harris Frank, Maplewood, N.J., Nicholas Joseph Bender, Raleigh, N.C., and Michael Charles Strycharz, Kingsport, Tenn.

The abstract of the patent published by the U.S. Patent and Trademark Office states: "The present teachings provide one or more surgical instruments for repairing damaged tissue, such as in the case of a hip or femoral fracture. The present teachings can also provide one or more orthopedic screws that can be inserted in and/or removed from bone using any of a dedicated driver or any of commonly available drivers. The present teachings can further provide a surgical instrument that includes dual reconstructive wires and associated method, among other instruments and methods for repairing a hip or femoral fracture." The patent application was filed on Oct. 16, 2008 (12/519,212). The full-text of the patent can be found at http://patft.uspto.gov/netacgi/nph-Parser Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&co1=AND&d=PTXT&s1=8,394,103&OS=8,394,103&RS=8,394,103 Written by Neha Bharti; edited by Jaya Anand.

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