Cellular Biomedicine completes patient enrollment in Phase I liver cancer trial
Aug 30, 2013 (MarketLine via COMTEX) --
Cellular Biomedicine Group, a developer of cell therapies for the treatment of degenerative diseases, has completed patient enrollment in its Phase I trial to evaluate the safety and preliminary efficacy of TC-DC, or tumor stem cell specific dendritic cell, therapy for hepatocellular carcinoma, or HCC.
The Phase I clinical trial for TC-DC therapy for HCC is an open label clinical trial conducted with Shanghai's PLA 85 Hospital, which is a Liver Disease Center. The trial will evaluate the safety and efficacy in lowering the incidence of tumor recurrence and metastasis by means of autologous immune cell therapy in primary HCC patients following standard tumor resection and TACE chemotherapy.
Dr Cheng Xiang (Chase) Dai, Cellular Biomedicine Group's VP and GM of the Autologous Products Business Unit, said, "We are pleased with this important achievement in the advancement of our therapy for liver cancer, and are on schedule to complete the Phase I trial in Q4 of this year."
TC-DC therapy takes a sample of the patient's own dendritic cells, which are the 'trainer' cells of effecter immune cells, and a sample of the patient's tumor stem cells, and co-cultures them together in the lab. The dendritic cells will learn the characteristics of the patient's own tumor stem cells, and are reintroduced to the patient's body as a vaccine, where they can 'train' the immune system to fight and destroy the tumor stem cells, which are the root cause of tumor recurrence and metastasis.
"One of the primary difficulties in administering effective cancer therapy is in the uniqueness of the disease; no two cancers are the same," explained Dr William Cao, President of CBMG, "Therefore, we source both immune and cancer stem cells directly from the patient so that each treatment is specific to each individual. In addition, rather than break down the cancer stem cell and use a portion of it, we use the whole cancer stem cell as the antigen source to stimulate the patient's own dendritic cells."
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