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Catalyst Biosciences Presents Two Posters on MarzAA at the 61st Annual American Society of Hematology ConferenceSOUTH SAN FRANCISCO, Calif., Dec. 09, 2019 (GLOBE NEWSWIRE) -- Catalyst Biosciences, Inc. (NASDAQ: CBIO), a clinical-stage biopharmaceutical company developing novel treatments for hemophilia and other rare bleeding disorders, today announced two poster presentations on Marzeptacog alfa (activated) – MarzAA, the Company’s subcutaneously administered next-generation engineered coagulation Factor VIIa (FVIIa), at the 61st Annual American Society of Hematology (ASH) meeting held December 7-10, 2019 in Orlando, Florida. In the first poster, entitled: Fast Onset of Action of Subcutaneously Administered Marzeptacog Alfa (Activated) Supports On-Demand Treatment in Hemophilia A Mice, Dr. Grant Blouse, PhD, vice president of translational research at Catalyst Biosciences presented data demonstrating MarzAA’s potential as an on-demand therapy to treat acute ongoing bleeding in hemophilia. The study evaluated the effect of subcutaneously (SQ) dosed MarzAA as a rescue therapy in a hemophilia A (HA) mouse model of severe bleeding. Bleeding was significantly reduced and was comparable to that of intravenous (IV) NovoSeven®. In the second poster, entitled: The Combination of Marzeptacog Alfa (Activated) or Eptacog Alfa (Activated) with Emicizumab Appears Comparable as Assessed by the Thrombin Generation Test in Hemophilia A Plasma Dr. Blouse presented data showing that MarzAA and NovoSeven exhibit comparable characteristics when spiked into Hemophilia A plasma containing Hemlibra® at clinically relevant concentrations and assessed by a standard thrombin generation assay. Based on these data, MarzAA is expected to be safe in combination with Hemlibra. Together with the fast onset data described above, this provides a rationale for the clinical development of MarzAA as a SQ rescue therapy for individuals with Hemophilia A experiencing breakthrough bleeds while on Hemlibra prophylaxis. “The data presented in these posters demonstrate the broad potential of MarzAA as an effective and safe SQ therapy in hemophilia and fuels our commitment to initiate a MarzAA Phase 3 study in 2020. We believe MarzAA could significantly improve the quality of life of individuals with Hemophilia or other bleeding disorders,” said Nassim Usman, Ph.D., president and chief executive officer of Catalyst. “There is a significant need for a safe, subcutaneously administered treatment and we believe MarzAA could play an important role in improving these individuals’ lives.” About Catalyst Biosciences Forward-Looking Statements Contact: |