|[January 28, 2013]
TetraLogic Pharmaceuticals Announces Decision to Grant Japanese Patent on Birinapant
MALVERN, Pa. --(Business Wire)--
TetraLogic Pharmaceuticals today announced that the Japan Patent Office
(JPO) issued a Decision to Grant the company a patent that claims
birinapant, a Smac mimetic currently in Phase 2 clinical studies for the
treatment of various cancers. The allowed Japanese patent application,
JP 2007-557249, has claims directed to the class of Smac mimetics that
encompasses birinapant as a new chemical entity (NCE) and to drug
products comprising birinapant and structurally related Smac mimetics.
A Decision to Grant is issued after the JPO makes a determination that a
patent can be granted from an application. The issued patent would have
a term that expires no earlier than in 2026.
This application is part of an expanding international patent portfolio
for TetraLogic with Japan being the ninth country to acknowledge the
patentability of the company's Smac mimetics. Others include the United
States, People's Republic of China, Eurasian Patent Office (which
incudes Russia), Australia, India, Mexico, Singapore and outh Africa.
Additional counterpart patent applications are pending examination in
Europe, Brazil, Canada, Israel, and Korea.
Additional patent applications that claim birinapant specifically, as
well as methods of using birinapant, are also pending around the world.
One of these that has claims directed specifically to birinapant was
issued in the United States as US Patent Number 8,283,372.
Birinapant (formerly TL32711) is a small molecule peptidomimetic of Smac
(Second mitochondrial-derived activator of caspases) that selectively
antagonizes the Inhibitor of Apoptosis (IAP) Proteins. Birinapant
rapidly degrades IAPs and enables TNFa and TRAIL to activate the
extrinsic apoptosis pathway, while it rapidly turns off the canonical
NF-?B survival pathway, causing cancer cell death. Birinapant has
entered Phase 2 clinical development for several solid tumors and a
Phase 1/2 study in acute myeloid leukemia (AML) is ongoing. In clinical
studies to date, birinapant has been well tolerated and demonstrated
effective suppression of IAPs and anti-cancer activity.
About TetraLogic Pharmaceuticals
TetraLogic Pharmaceuticals is a privately held biopharmaceutical company
that is developing Smac mimetics, small molecule drugs that mimic Smac
for the treatment of cancers. The company's institutional investors
include Clarus Ventures, HealthCare Ventures, Quaker Partners, Novitas
Capital, Nextech Invest Ltd, Hatteras Venture Partners, Pfizer Ventures,
Latterell Venture Partners, the Vertical Group, Amgen Ventures, and
Kammerer Associates. For additional information, please refer to the
company's Web site at www.tetralogicpharma.com.
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